解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::This report describes the production and cytology of the first interspecific hybrids between cultivated alfalfa (Medicago sativa L.) at the diploid level (2n = x = 16) and the diploid (2n = 2x = 16) perennial species M. daghestanica and M. pironae. An ovule-embryo culture technique was required to rescue hybrid embryo...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g93-080
更新日期:1993-06-01 00:00:00
abstract::The standard karyotype and a wide array of repatterned cytotypes from 21 demes of the double-allotriploid thelytokous Bacillus lynceorum have been analyzed by means of Giemsa, C-banding, and silver-staining techniques. The present study substantially amends the first karyotype description and also analyzes in detail t...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g93-044
更新日期:1993-04-01 00:00:00
abstract::Resistance to common root rot and black point, caused by Cochliobolus sativus, was evaluated in alien chromosome substitution and addition lines of the cultivars 'Cadet' and 'Rescue'. Substitution of chromosome 5B in 'Rescue' with 5Ag from Agropyron elongatum decreased root rot susceptibility to a level intermediate b...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g93-023
更新日期:1993-02-01 00:00:00
abstract::Quantitative trait loci (QTL) controlling traits associated with winterhardiness in barley (field survival, LT50, growth habit, and crown fructan content) were mapped to chromosome 7 in a population of 100 F1-derived doubled haploid lines. The largest QTL effects for all traits were detected in a 21% recombination int...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g93-009
更新日期:1993-02-01 00:00:00
abstract::The DNA sequencing and preliminary functional analysis of a 32 kb section of yeast chromosome I has been completed. This region lies on the left arm of the chromosome between the LTE1 and SPO7 genes and contains 14 open reading frames (ORFs) positioned closely together, with an average spacing of approximately 350 nuc...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g93-005
更新日期:1993-02-01 00:00:00
abstract::The present study constitutes the first attempt to construct a photographic map of the polytene chromosomes of Dacus oleae, a pest of the olive tree that causes serious financial damage in all olive oil producing countries. The map was constructed by using the larval fat body cells, the chromosomes of which are repres...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g92-056
更新日期:1992-06-01 00:00:00
abstract::Genetic parameters were estimated on growth and development traits using analyses of variance and covariance of 42 full-sib families from a select line, 39 full-sib families from a control line of the same strain, and 37 full-sib families from another unselected strain. The traits included percent 1+ smolts, percent s...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g92-046
更新日期:1992-04-01 00:00:00
abstract::Polymerase chain reaction was used, with single 10-mer primers of arbitrary sequence, to amplify random regions of genomic DNA from a diploid cultivated alfalfa backcross population. Segregation of the random amplified polymorphic DNA (RAPD) fragments was analysed to determine if RAPD markers are suitable for use as g...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g92-014
更新日期:1992-02-01 00:00:00
abstract::Spermatocytes at meiotic metaphase I and anaphase I have a characteristic centromeric filament in a variety of vertebrate organisms. This centromeric filament was first demonstrated on mouse spermatocytes and its presence is now extended to spermatocytes from the human, rat, golden hamster, bull, and chicken. The visu...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g91-136
更新日期:1991-12-01 00:00:00
abstract::A putative old and ubiquitous interspersed DNA repeat family was identified from TaqI restriction, M13 cloning, and sequencing of the genomic DNA of a Mallard (Anas platyrhynchos), a Muscovy Duck (Cairina moschata), a Toulouse Goose (Anser anser), and a Black Swan (Cygnus atratus). A 425-bp consensus core sequence was...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g91-075
更新日期:1991-06-01 00:00:00
abstract::A survey of restriction fragment polymorphism in mitochondrial DNA (mtDNA) of 17 populations of the mosquito Aedes albopictus was undertaken. The mtDNA size was estimated to be about 17.5 kbp. The level of polymorphism was low, with over 99% of the fragments being shared in common among the 17 populations. Three popul...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g91-046
更新日期:1991-04-01 00:00:00
abstract::Restriction endonuclease TaqI has been known as a nonbanding restriction endonuclease when it is used on fixed human chromosomes. However, a specific TaqI digestion can be obtained after varying experimental conditions such as concentration of enzyme, time of incubation, and volume of the final reaction mixture. This ...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g91-039
更新日期:1991-04-01 00:00:00
abstract::Five nonallelic copies of the dispersed (GATA)n repeated sequence of Drosophila melanogaster (referred to as GATA elements) have been sequenced and analysed. The GATA elements range in size from 111 to 444 bp, consisting predominantly of tandemly repeated GATAs, interspersed with variants of the subunit. The types and...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g90-113
更新日期:1990-10-01 00:00:00
abstract::The chromosome makeup of a 3-year-old crossbred heifer was examined in an attempt to explore the cytogenetic causes of her infertility. The heifer proved to be a mosaic carrying predominantly XY cells and with approximately 30% of cells lacking a normal Y. The minor population included cells carrying a dicentric isoch...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g90-104
更新日期:1990-10-01 00:00:00
abstract::Although little is known about the molecular organization of most genes within heterochromatin, the unusual properties of these chromosomal regions suggest that genes therein may be organized and expressed very differently from those in euchromatin. We report here the cloning, by P transposon tagging, of sequences ass...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g90-062
更新日期:1990-06-01 00:00:00
abstract::Southern hybridization analysis of Indian muntjac genomic DNA with the Eco-Taq bovine genomic protamine probe revealed a simple banding pattern. The pattern of hybridization was identical with that previously observed in the genus Bos. This suggested that the bovine probe specifically hybridized to the Indian muntjac ...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g90-068
更新日期:1990-06-01 00:00:00
abstract::We examined the sequence of a 2214 base pair HindIII fragment from the mitochondrial genome of six rainbow trout. The fragment encodes four proteins and two tRNAs. Sequences for two fish from a single locality were identical. Those from separate localities differed by from 1 to 7 nucleotide substitutions. Of 13 variab...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g90-003
更新日期:1990-02-01 00:00:00
abstract::GATA-GACA repetitive sequences first isolated from a female snake (termed BKm sequences) and associated with sex chromosomes in some species were hybridized to DNA from rainbow trout (Salmo gairdneri). Genomic DNA was studied from three groups of rainbow trout: (i) randomly selected males and females from an outbred g...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g89-523
更新日期:1989-10-01 00:00:00
abstract::Two periods of the development of genetic research in the USSR with reference to its current trends of plant and animal genetics, cytogenetics, and molecular genetics are reviewed. A short list of priority areas is established: the maintenance and use of unique gene pools of plants and animals; the domestication of an...
journal_title:Genome
pub_type: 历史文章,杂志文章
doi:10.1139/g89-160
更新日期:1989-01-01 00:00:00
abstract::All mRNAs on the yeast mitochondrial genome terminate at a conserved dodecamer sequence 5'-AAUAAUAUUCUU-3'. We have characterized two mutants with altered dodecamers. One contains a deletion of the dodecamer at the end of the var1 gene, and the other contains two adjacent transversions in the dodecamer at the end of t...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g89-134
更新日期:1989-01-01 00:00:00
abstract::We have used immunocytochemistry and molecular cloning methods to identify and characterize structural polypeptides of the centromere. These studies permit us to resolve two distinct regions: the inner and outer centromere. (i) Components of the outer centromere: autoantibodies from certain patients with rheumatic dis...
journal_title:Genome
pub_type: 杂志文章,评审
doi:10.1139/g89-103
更新日期:1989-01-01 00:00:00
abstract::Mapping and sequencing the human genome will generate large amounts of data, which must be sorted, analyzed, and stored for rapid retrieval to complete this enormous task. Computers and their software programs provide the most important tool to the molecular biologist today. A discussion of current capabilities and fu...
journal_title:Genome
pub_type: 杂志文章,评审
doi:10.1139/g89-177
更新日期:1989-01-01 00:00:00
abstract::Conceptual aspects of estimation of genetic components of variance and covariance under selection are discussed, with special attention to likelihood methods. Certain selection processes are described and alternative likelihoods that can be used for analysis are specified. There is a mathematical relationship between ...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g89-136
更新日期:1989-01-01 00:00:00
abstract::Mismatched heteroduplexes arise as intermediates of several dissimilar genetic processes. The outcome of these genetic events will therefore be influenced by the efficiency and specificity of mismatch repair. We have studied the correction of base-base mispairs in simian and human fibroblasts by transfecting the cells...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g89-107
更新日期:1989-01-01 00:00:00
abstract::Both meiosis-specific and general recombination functions, recruited from the mitotic cell cycle, are required for elevated levels of recombination and for chromosome synapsis (assembly of the synaptonemal complex) during yeast meiosis. The meiosis-specific SPO11 gene (previously shown to be required for meiotic recom...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g89-017
更新日期:1989-01-01 00:00:00
abstract::The morphological picture of primate phylogeny has not unambiguously identified the nearest outgroup of Anthropoidea and has not resolved the branching pattern within Hominoidea. The molecular picture provides more resolution and clarifies the systematics of Hominoidea. Protein and DNA evidence divides Hominoidea into...
journal_title:Genome
pub_type: 杂志文章,评审
doi:10.1139/g89-050
更新日期:1989-01-01 00:00:00
abstract::Some aspects of Wright's great contribution to quantitative genetics and animal breeding are reviewed in relation to current research and practice. Particular aspects discussed are as follows: the utility of his definition of inbreeding coefficient in terms of the correlation of uniting gametes; the maintenance of gen...
journal_title:Genome
pub_type: 传,历史文章,杂志文章,评审
doi:10.1139/g89-033
更新日期:1989-01-01 00:00:00
abstract::The molecular analyses of three of the regulatory genes (transformer (tra), doublesex (dsx), and transformer-2 (tra-2)) controlling sexual differentiation in Drosophila have demonstrated that the control of RNA processing has a major role in regulating somatic sexual differentiation. The activities of both the tra and...
journal_title:Genome
pub_type: 杂志文章,评审
doi:10.1139/g89-117
更新日期:1989-01-01 00:00:00
abstract::Gene segregation at six protein loci was analysed in progeny from tetraploid males and females obtained by suppression of first mitosis. The triploid full-sib families from five tetraploid males and the diploid gynogenetic lines from four tetraploid females were examined. The proportions of heterozygous gametes (0.83 ...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g88-092
更新日期:1988-08-01 00:00:00
abstract::A recent investigation, using a human genomic probe, has indicated that the 68,000 dalton neurofilament gene (NF68) is on the short arm of chromosome 8. We have used a murine cDNA probe on 65 metaphase spreads in situ to localize the human NF68 gene to 8p21 (20/370 grains; p less than 0.0001). In addition, we have fou...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g88-083
更新日期:1988-08-01 00:00:00
abstract::Electron microscopic examination of gonads of Drosophila melanogaster with different genotypes, including a metafemale 3X;2A and an intersex XXY;3A have revealed that the formation of synaptonemal complexes is controlled by the genic balance, i.e., the ratio of X chromosomes to autosomes. The Y chromosome is not invol...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g88-044
更新日期:1988-04-01 00:00:00
abstract::Hamster beta-tubulin (detected as a mutant subunit that confers Colcemid resistance) is either not expressed or is underexpressed in Chinese hamster-mouse somatic cell hybrids. This selectivity of tubulin expression suggests that a uniparental mouse spindle might preferentially engage mouse chromosomes and lead to los...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g87-090
更新日期:1987-08-01 00:00:00
abstract::We have studied the effect of gamma radiation on recombination frequency for intervals across the cluster of linkage group I in Caenorhabditis elegans. Recombination frequency increased approximately twofold across the dpy-5-unc-13 interval after treatment with 2000 rads (1 rad = 10 mGy) of cobalt 60 gamma radiation. ...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g87-079
更新日期:1987-06-01 00:00:00